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Explanation of CLPS Test Results


This dog is homozygous N/N, with two normal copies of the gene. This dog can only transmit the normal gene to its offspring. This dog will not produce puppies with cleft palate, cleft lip or syndactyly caused by the CLPS mutation. In the NSDTR there are other inherited forms of cleft palate. This test does not give any information about those other forms of cleft palate.


This dog is heterozygous CLPS/N, with one mutated copy of the gene and one normal copy of the gene, and is classified as a carrier. This dog can transmit the abnormal copy of the gene to its puppies and therefore if bred to another carrier of CLPS can produce puppies with cleft palate, cleft lip or syndactyly.


No dogs have ever been identified that were homozygous for CLPS that did not have cleft palate, cleft lip or syndactyly in over 500 dogs tested. We offer testing of puppies with cleft palate at no cost in order to determine if the puppy has the CLPS form of cleft or another form. Please contact Zena Wolf for more information at ztwolf@ucdavis.edu. These tests will be performed on a research basis.


Canine Health Information Center (CHIC)

Canine Health Foundation

Morris Animal Foundation

Animal Health Trust

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